A Flexible Modeling Platform for Lung Cancer
Oncology is an area of immense clinical need and a primary driver of healthcare spending, making it a prime target for assessment of the value of available medical interventions. Of the many forms of cancer, lung cancer is the leading cause of cancer-related deaths worldwide.(1) The American Cancer Society estimates that of the 1,735,000 new cancer cases in the U.S. in 2018, 13.5% will be lung cancer. NSCLC accounts for an estimated 85% of lung cancer cases and comprises adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.(2)
IVI’s first oncology-specific Open-Source Value Platform (OSVP) model focuses on non-small cell lung cancer (NSCLC). Specifically, the IVI-NSCLC model examines the value of sequential treatment strategies for patients with epidermal growth factor receptor positive (EGFR+) NSCLC, which accounts for 8% of new NSCLC cases.(3)
Patient Perspective at the Heart of Model Development
Patients are an indispensable voice in developing any platform or model that may affect healthcare decision-making. The IVI-NSCLC platform was developed in partnership with the LUNGevity Foundation, in keeping with IVI’s commitment to seek patients and patient organizations as research partners to better understand drivers of patient-centered value. LUNGevity provided critical input on model development, beginning with early planning and the identification of EGFR+ NSCLC as the focus of the model. Throughout model development, LUNGevity has provided ongoing review, feedback, and direction.
With guidance from LUNGevity, IVI also conducted qualitative research with NSCLC patients to better understand their perspectives on value, what they consider and worry about when making treatment decisions, and how they prioritize one aspect versus another. The findings from this research directly inform the ongoing development of the IVI-NSCLC model. Findings from research will also feed directly into a related “Quantifying the Patient Experience” study in which IVI is developing NSCLC-specific measures of quality of life incorporating different treatment modalities. The results of this latter study will be incorporated into Version 2 of the OSVP model.
User Input Improves the IVI-NSCLC Model
Public Feedback Drives Model Development
The Open-Source Value Platform allows for iterative and collaborative development of all modeling platforms in order to incorporate diverse perspectives.
We want to hear from you! From sharing your perspective on what factors should be included in IVI’s measurement of value, to recommending changes to the underlying source code and user interfaces, we encourage all stakeholders to share your thoughts as part of the public feedback period. Make your voice heard and contribute to the open source process.
Timeline for Feedback, Review, and Revision
We invite you to provide feedback on Version 1 of the IVI-NSCLC model at any point during the public comment period, which concludes on April 1, 2019.
Following the public comment period, a Technical Expert Panel (TEP) of subject-matter experts will review all feedback and suggestions received and develop prioritized recommendations for improvement of the IVI-NSCLC model. These recommendations will guide revisions and model improvements in Version 2 of the IVI-NSCLC model.
The OSVP process is fully transparent. All public comments, TEP reviews and recommendations, and IVI plans for model revision will be made publicly available on our website.
Learn More About the IVI-NSCLC Model
How does the IVI-NSCLC Model work?
The IVI-NSCLC model is an open-source simulation model that decision-makers can use to assess the value of different sequences of treatment of non-small cell lung cancer (NSCLC). Specifically, the IVI-NSCLC model provides information on expected health benefits, risks and costs for patients with EGFR+ NSCLC.
There is a lot to learn about the IVI-NSCLC model. Get started with the links below.
- Incorporating the patient perspective. See how we work with patients and other stakeholders to build Open-Source Value Platform models.
- Application in the real world. Learn about the mechanics of the IVI-NSCLC model and see specific examples of how it can be used.
- Review detailed methodology. Click here to learn more about the technical details on how the IVI-NSCLC model is constructed.
Many Ways to Use the IVI-NSCLC Model
There are multiple ways to use the IVI-NSCLC model, with options for a wide range of users – from those new to modeling to expert programmers.
- IVI-NSCLC Basic Value Tool. This interactive online tool provides a streamlined experience requiring no existing expertise. (Optimized for use with Google Chrome; some features may not be supported in other browsers.)
- IVI-NSCLC Advanced Value Tool. For users who want control over all the modeling parameters and structural assumptions, this interface provides an interactive online tool for running more customized analyses with the IVI-NSCLC model. (Optimized for use with Google Chrome; some features may not be supported in other browsers.)
- iviNSCLC R Package. The R package is available for users who would like to fully customize their analyses.
- Source Code. Complete source code for the IVI-NSCLC model is available for download and adaptation.